Cardiopulmonary and respiratory sequelae of preterm birth
Another area of research in the lab is to better understand pulmonary gas exchange in health and diseases such as asthma and survivors of bronchopulmonary dysplasia (BPD). Although it is known that these subjects with asthma and BPD suffer from lung-related issues, they may also be at risk for problems associated with cardiovascular dysfunction because of effects secondary to their lung diseases (Lovering et al., High Altitude Medicine & Biology, 2007). Understanding the full physiologic effects of these diseases is critical for gaining a better understanding of how to develop an effective overall treatment plan for these patients.
The major goals of these projects in adults are to: 1) quantify pulmonary gas exchange efficiency at rest and during exercise in normoxia and hypoxia, 2) quantify cardiopulmonary interactions (cardiac output , pulmonary artery pressure, etc) at rest and during exercise in normoxia and hypoxia, 3) determine the contribution of intrapulmonary shunting to the gas exchange inefficiency that occurs during, and 4) determine the degree of cardiovascular dysfunction at rest and during exercise.
Funding for this work provided by: American Heart Association Scientist Development GrantThe major goals of these projects in children are to: 1) quantify pulmonary gas exchange efficiency at rest and during exercise in normoxia, 2) quantify cardiopulmonary interactions (cardiac output , pulmonary artery pressure, etc) at rest and during exercise in normoxia, and 3) determine the effectiveness of varying interventions on pulmonary rehabilitation and cardiopulmonary performance. Some of this work is being conducted with my collaborator Dr. Mike Stickland at the University of Alberta in Edmonton, Canada.
Funding for this work is provided by: Alberta Health Services Emerging Teams Grant.
 |
 |
 |
 |
