George von Dassow
The cells composing invertebrate embryos perform – in a great hurry, synchronously, and in large numbers – most of the fundamental behaviors that characterize all animal cells. My current research focus is the self-assembly and function of the cytoskeleton during embryonic cell division, especially during the induction and maintenance of the cytokinetic apparatus – the poorly-understood machine that actually pinches the cell in two. My collaborators and I use fluorescent-protein probes, micromanipulation, and time-lapse confocal microscopy to describe the dynamics and functional relations among microtubules, actomyosin, and key signaling molecules. While this is my main project recently, I'm generally interested in cell behavior during early development, and in the comparative embryology of invertebrates. I do not supervise graduate students, but I am available to work with undergraduates and eager to collaborate on microscopy or embryology.
G. von Dassow (2009) Concurrent cues for cytokinetic furrow induction in animal cells. Trends Cell Biology 19: 165-73.
V. E. Foe and G. von Dassow (2008) Stable and dynamic microtubules coordinately shape the myosin activation zone during cytokinetic furrow formation. J. Cell Biology 183: 457-70.
J. K. Baruni, E. M. Munro, and G. von Dassow (2008) Cytokinetic furrow induction in toroidal, binucleate, and anucleate C. elegans embryonic cells. J. Cell Science 121: 306-16.
B. Burkel, G. von Dassow, and W. M. Bement (2007) Simple, versatile probes for actin filaments. Cell Motility and the Cytoskeleton 64: 822-32.
W. M. Bement, A. L. Miller, and G. von Dassow (2006) Rho GTPase activity zones and transient contractile arrays. Bioessays 28: 983-93.
W. M. Bement, H. A. Benink, and G. von Dassow (2005) A microtubule-dependent zone of active RhoA during cleavage plane specification. J. Cell Biology 170: 91-101.
E. Meir, G. von Dassow, E. M. Munro, and G. M. Odell (2002) Robustness, flexibility, and the role of lateral inhibition in the neurogenic network. Current Biology 12: 778-86.
G. von Dassow, E. Meir, E. M. Munro, and G. M. Odell (2000) The segment polarity network is a robust developmental module. Nature 406: 188-92.
G. von Dassow and E. M. Munro (1999) Modularity in animal development and evolution: elements of a conceptual framework for EvoDevo. J. Exp. Zoology (Mol. Dev. Evol.) 285: 307-25.
G. von Dassow and G. Schubiger (1994) How an actin network might cause fountain streaming and nuclear migration in the syncytial Drosophila embryo. J. Cell Biology 127: 1637-53.