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From: "PI eAlert" <editor@principalinvestigatorsadvisors.org>
Subject: Your Issue: November 24, 2009
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<html><body class='st23804' ><table width='500' border='0' align='center' cellpadding='2' cellspacing='3' style='font-size:12px;'><tr> <td align='center'><p align='center'><a href='XXXXXXXprincipalinvestigatorsadvisors.org/view.php/612071/49772'>View this email as Webpage</a></p></td></tr></table><p align="center"><font size="1" face="sans-serif">Please add "<a href="mailto:editor@principalinvestigators.org">editor@principalinvestigators.org</a>" 
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<p align="left"><font style="FONT-SIZE: 7pt" face="sans-serif">PI e-Alert 
</font><font style="FONT-SIZE: 7pt" face="sans-serif">features expert advice on 
managerial and administrative challenges which confront Principal Investigators 
in every field of science research. If such matters are not of interest to you 
or your associates, please accept our apologies and &#8220;unsubscribe&#8221; at the bottom 
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<p align="right">No. 4, November 23-27, 2009</p>
<p><strong><font size="5" face="sans-serif"><span class="Apple-style-span" style="text-decoration: underline;"><span class="Apple-style-span" style="font-size: large;">Grant Clinic:</span></span></font></strong></p><p><strong><font size="5" face="sans-serif">Was "too ambitious" to blame for non-funding?</font></strong></p>
<p align="left"><font size="2"><strong>Reader Question: </strong><em>I recently received the 
reviewers' summary sheets for my first R01 research grant submission. The score 
was encouraging, but not fundable. The reviewers&#8217; criticisms, however, were all 
mild and addressable, and did not represent specific flaws in the work itself. 
Two reviewers commented that the program is an ambitious one, and that perhaps I 
need to cut back on at least two of the proposed studies. I could easily do 
that, so why didn&#8217;t I get the funding? What am I missing?</em></font> 
</p><p align="left"><strong>Expert Comments:</strong> Interpreting the thoughts of the reviewers 
is a road to madness, but I might be able to read between the lines here. First, 
you got hit with the dreaded &#8220;A&#8221; word &#8211; ambitious. This is code for &#8220;your 
inexperience is showing.&#8221; Reviewers want to see originality and novel ideas or 
methods to some extent, but they do not want to see a proposal for a project 
that is so unusual or aggressive that it may not be doable. You are sure you can 
do it and maybe you can. But, um, &#8220;stuff happens&#8221;, and all of a sudden 
recruitment becomes sparse, a reagent was contaminated, something else goes 
wrong, and&nbsp;</p>
<p align="right"><font size="2"><a href="XXXXXXXprincipalinvestigatorsadvisors.org/go.php/612071/49772/4031854" target="_blank">View the remainder of the expert comments</a></font></p>
<p><font size="2"><em>Comments by <strong>William Gerin, </strong>Ph.D., P.I. e-Alert&#8217;s Chief Grants Consultant, Professor of Biobehavioral Health, Pennsylvania State University, and Author, <span class="Apple-style-span" style="text-decoration: underline;">Writing the NIH Grant Proposal: A Step-by-Step Guide, SAGE Books (2006)</span>&nbsp; </em></font></p><p align="center"><font size="2">Agree? Disagree? <a href="XXXXXXXprincipalinvestigatorsadvisors.org/go.php/612071/49772/4031877" target="_blank">Submit your comments</a></font></p></td></tr>
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<p align="center"><strong><em><font size="4" face="Times New Roman">&#9658;&#9658;</font><font size="4" face="sans-serif">Preview of Next Week's Question</font><font size="4" face="Times New Roman">&#9668;&#9668;</font></em></strong></p>
<p align="right"><font size="2">No. 5, November 30-December 4, 2009</font></p><font size="2">
<p align="left"><font size="2"><strong>Reader Question:<em>&nbsp;<span class="Apple-style-span" style="font-weight: normal; ">As PIs, we understand of course that research fraud is intolerable. However, at times misleading data could be reported to a journal or sponsor merely because of a serious, though fully accidental, mistake in recordkeeping, faulty statistical calculations etc. Does such a mixup constitute "fraud"? What is the difference in the eyes of granting agencies and legal doctrine? When and how does "accident" cross over to PI "crime"?</span></em></strong></font></p>
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<p align="center"><strong><em><font size="2" face="sans-serif">Missed Last Weeks's 
Question?</font></em></strong> 
</p><p align="left"><font size="2"><strong>Reader Question: </strong><em>We have a new scientist coming to my lab from China, but a corporate sponsor of our research only wants U.S. citizens working on the project. We aren&#8217;t doing any kind of top secret or classified work, so this request came as a real surprise to us. Does the sponsor have a right to do this? Are there any other things we need to be aware of in having a non-U.S. citizen working in our lab?&nbsp;</em></font></p><p align="right"><font size="2"><a href="XXXXXXXprincipalinvestigatorsadvisors.org/go.php/612071/49772/4031946" target="_blank">View the expert comments</a></font></p>
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