Research

Soft matter physics aims to understand complex materials and systems that owe their physical properties to interactions among mesoscopic building blocks, often strongly influenced by disorder and stochastic fluctuations. From its origins in studies of polymers and liquid crystals, the field of soft matter has grown to encompass a wide range of systems and techniques.

Our group works on a variety of problems involving elasticity, mechanics, and statistical physics, with two main sources of inspiration:

  • Designer matter: Thanks to advances in fabrication techniques ranging from rapid prototyping to self-assembly, we have an ever-improving ability to fabricate desired structures across varied length scales. This motivates the question: if we can build any material, what should we build? How do we design structures that harbour novel and potentially useful mechanical properties?

  • Biology: Biological structures such as DNA, cell membranes and the cytoskeleton are textbook examples of “soft matter”, whose shape and mechanical properties emerge from interactions among mesoscopic building blocks and are strongly influenced by stochastic forces due to temperature and active metabolic processes. Geometry and randomness are also key players in the propagation of genetic information through time and space during evolution.

These problems are tackled through a combination of theoretical and computational techniques. We also benefit from collaborations with experimental groups and from conducting our own laboratory demonstrations when the opportunity arises.

Below are summaries of current and past research projects under these themes.

Designer matter

Active metamaterials

Active matter refers to collective states of interacting, dynamic agents which expend energy. Rooted in studies of living systems such as bird flocks and the cytoskeleton, the field is now exploring ways in which artificial materials with dynamical elements may display mechanical properties with novel and potentially desirable features. How do classical notions of materials science, such as elasticity and rigidity, translate to such active materials? What new frameworks and techniques might we need to design, assemble, and characterize them?

Publications:

Nondispersive One-Way Signal Amplification in Sonic Metamaterials
N Kruss, J Paulose
Physical Review Applied 17, 024020 (2022)
Stopping and Reversing Sound via Dynamic Dispersion Tuning in a Phononic Metamaterial
P Karki, J Paulose
Physical Review Applied 15, 034083 (2021)
Spatiotemporal order and emergent edge currents in active spinner materials
BC van Zuiden, J Paulose, WTM Irvine, D Bartolo, V Vitelli
PNAS 113, 12919 (2016) [PDF] [arXiv]

Topological soft matter

The topological bulk-boundary correspondence is a powerful concept in condensed matter physics, which links the edge excitations of a structure (whether of electrons, light, or sound) to a topological invariant that characterizes its bulk. As a result, these edge modes are robust against a wide range of perturbations as long as they do not change the bulk invariant. We have designed repeating structures, or metamaterials, with robust mechanical properties of topological origin. We are also exploring the realization of topologically protected phenomena in polymer physics.

Publications:

Topological Protection Can Arise from Thermal Fluctuations and Interactions
RP Pedro, J Paulose, A Souslov, M Dresselhaus, V Vitelli
Physical Review Letters 122, 118001 (2019)
Localizing softness and stress along loops in 3D topological metamaterials
G Baardink, A Souslov, J Paulose, V Vitelli
Proceedings of the National Academy of Sciences 115, 489 (2018) [arXiv]
Geared Topological Metamaterials with Tunable Mechanical Stability
A Meeussen, J Paulose, V Vitelli
Phys. Rev. X 6, 041029 (2016) [PDF]
Selective buckling via states of self-stress in topological metamaterials
J Paulose, A Meeussen, V Vitelli
PNAS 112, 7639 (2015) [PDF] [arXiv]
Topological modes bound to dislocations in mechanical metamaterials
J Paulose, BG Chen, V Vitelli
Nature Physics 11, 153 (2015) [PDF] [arXiv]

(Chosen for the cover of the February 2015 issue of Nature Physics, and with an accompanying commentary.)

Biophysics and evolutionary dynamics

Long-range dispersal and genetic diversity

The spreading of genetic information over long distances is common in nature, from wind- and water-borne seeds and microbes to the hitchhiking of pathogens on air travellers. By providing access to virgin territory with little competition, even rare long-distance dispersal events can dramatically accelerate the spread of a species or a beneficial mutation within a species. We aim to understand the population structures that can arise when multiple mutations, which may be neutral relative to each other or confer some defined fitness advantage, spread through a population with the help of long-range dispersal events. Do such populations end up being more or less diverse than populations where genetic information spreads locally? What are the signatures of long-range dispersal in genetic data such as site frequency spectra?

Publications:

Branching Structure of Genealogies in Spatially Growing Populations and Its Implications for Population Genetics Inference
A Eghdami, J Paulose, D Fusco
Journal of Physics: Condensed Matter 34, 294008 (2022)
The Impact of Long-Range Dispersal on Gene Surfing
J Paulose, O Hallatschek
Proceedings of the National Academy of Sciences 117, 7584 (2020)
Spatial Soft Sweeps: Patterns of Adaptation in Populations with Long-Range Dispersal
J Paulose, J Hermisson, O Hallatschek
PLOS Genetics 15, e1007936 (2019)

Elasticity and geometry of thin-walled structures

The mechanics of thin shells governs the stiffness and response of many biological structures such as bacterial and plant cell walls and the outer protein shell of viruses. In contrast to macroscopic shell structures, living shells are dynamic objects buffetted by thermal fluctuations and by the molecular machinery involved in growth and replication. Understanding their elastic response entails combining classical shell theory with equilibrium and nonequilibrium statistical mechanics to take into account the effects of stochastic forces. Spatial inhomogeneities in stiffness and the addition of material due to growth are also important considerations. The goal is to develop an expanded shell theory framework that could be applied to biological problems such as shape regulation in cell wall growth and mechanical degradation of viruses.

Publications:

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
M Pelliccia, P Andreozzi, J Paulose et al
Nature Communications 7, 13520 (2016) [PDF]
Buckling pathways in spherical shells with soft spots
J Paulose, DR Nelson
Soft Matter 9, 8227 (2013) [PDF]
Fluctuating shells under pressure
J Paulose, G Vliegenthart, G Gompper, DR Nelson
PNAS 109, 19551 (2012) [PDF]