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C. elegans is a powerful model system for studying genetics, development, and neurobiology. The Phillips lab has helped pioneer the use of this species for evolutionary studies, particularly for experimental evolution. We are expanding this work into the molecular population genomic analysis of the closely related species, C. remanei, which has much more genetic variation.

 

Phillips Laboratory

publications

Google Scholar record for Patrick Phillips


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  2024 (3)
Heritable epigenetic variation facilitates long-term maintenance of epigenetic and genetic variation. Webster, A. K; and Phillips, P. C G3: Genes, Genomes, Genetics, 14(2): jkad287. 2024.
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Patterns of Genomic Diversity in a Fig-Associated Close Relative of Caenorhabditis elegans. Woodruff, G. C; Willis, J. H; and Phillips, P. C Genome Biology and Evolution, 16(2): evae020. 2024.
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Expansion of the split hygromycin toolkit for transgene insertion in Caenorhabditis elegans. Moerdyk-Schauwecker, M. J; Jahahn, E. K; Muñoz, Z. I; Robinson, K. J; and Phillips, P. C Micropublication Biology, 2024. 2024.
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  2023 (7)
Widespread changes in gene expression accompany body size evolution in nematodes. Woodruff, G. C; Willis, J. H; Johnson, E.; and Phillips, P. C bioRxiv. 2023.
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Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes. Banse, S. A; Sedore, C. A; Johnson, E.; Coleman-Hulbert, A. L; Onken, B.; Hall, D.; Jackson, E G.; Huynh, P.; Foulger, A. C; Guo, S.; and others GeroScience,1–13. 2023.
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High-throughput library transgenesis in Caenorhabditis elegans via Transgenic Arrays Resulting in Diversity of Integrated Sequences (TARDIS). Stevenson, Z. C; Moerdyk-Schauwecker, M. J; Banse, S. A; Patel, D. S; Lu, H.; and Phillips, P. C Elife, 12: RP84831. 2023.
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Genomic diversity landscapes in outcrossing and selfing Caenorhabditis nematodes. Teterina, A. A; Willis, J. H; Lukac, M.; Jovelin, R.; Cutter, A. D; and Phillips, P. C PLoS Genetics, 19(8): e1010879. 2023.
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Post-insemination sexual selection in males indirectly masculinizes the female transcriptome. Kasimatis, K. R; Willis, J. H; and Phillips, P. C bioRxiv,2023–08. 2023.
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The Egg-Counter: A novel microfluidic platform for characterization of Caenorhabditis elegans egg-laying. Banse, S. A; Jarrett, C. M; Robinson, K. J; Blue, B. W; Shaw, E. L; and Phillips, P. C bioRxiv. 2023.
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Epigenetic context predicts gene expression variation and reproductive traits across genetically identical individuals. Webster, A. K; Willis, J. H; Johnson, E.; Sarkies, P.; and Phillips, P. C bioRxiv,2023–10. 2023.
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  2022 (8)
Slow recovery from inbreeding depression generated by the complex genetic architecture of segregating deleterious mutations. Adams, P. E; Crist, A. B; Young, E. M; Willis, J. H; Phillips, P. C; and Fierst, J. L Molecular Biology and Evolution, 39(1): msab330. 2022.
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Post-insemination selection dominates pre-insemination selection in driving rapid evolution of male competitive ability. Kasimatis, K. R; Moerdyk-Schauwecker, M. J; Lancaster, R.; Smith, A.; Willis, J. H; and Phillips, P. C PLoS Genetics, 18(2): e1010063. 2022.
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Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes. Onken, B.; Sedore, C. A; Coleman-Hulbert, A. L; Hall, D.; Johnson, E.; Jones, E. G.; Banse, S. A; Huynh, P.; Guo, S.; Xue, J.; and others Aging cell, 21(1): e13488. 2022.
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The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background. Banse, S. A; Jackson, E G.; Sedore, C. A; Onken, B.; Hall, D.; Coleman-Hulbert, A.; Huynh, P.; Garrett, T.; Johnson, E.; Harinath, G.; and others bioRxiv,2022–01. 2022.
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Genetic diversity estimates for the Caenorhabditis Intervention Testing Program screening panel. Teterina, A. A; Coleman-Hulbert, A. L; Banse, S. A; Willis, J. H; Perez, V. I; Lithgow, G. J; Driscoll, M.; and Phillips, P. C MicroPublication Biology, 2022. 2022.
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Opposing directions of stage-specific body shape change in a close relative of C. elegans. Hammerschmith, E. W; Woodruff, G. C; Moser, K. A; Johnson, E.; and Phillips, P. C BMC zoology, 7(1): 38. 2022.
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ROBUST LONGEVITY EFFECTS OF NOVEL COMPOUNDS TESTED BY THE CAENORHABDITIS INTERVENTION TESTING PROGRAM. Driscoll, M.; Onken, B.; Sedore, C.; Coleman-Hulbert, A.; Hall, D.; Lithgow, G.; Phillips, P.; and Montes, V. P. Innovation in Aging, 6(Supplement_1): 814–814. 2022.
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ANTI-AGING COMPOUNDS METFORMIN AND THIOFLAVIN T CAN ACT ON GENETICALLY DIVERSE, PROTEOSTASIS-COMPROMISED STRAINS. Driscoll, M.; Onken, B.; Xu, Y.; Song, Y.; Achanta, M.; Sedore, C.; Phillips, P.; and Lithgow, G. Innovation in Aging, 6(Supplement_1): 806–807. 2022.
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  2021 (6)
Complex pleiotropic genetic architecture of evolved heat stress and oxidative stress resistance in the nematode Caenorhabditis remanei. O’Connor, C. H; Sikkink, K. L; Nelson, T. C; Fierst, J. L; Cresko, W. A; and Phillips, P. C G3, 11(4): jkab045. 2021.
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Evaluating human autosomal loci for sexually antagonistic viability selection in two large biobanks. Kasimatis, K. R; Abraham, A.; Ralph, P. L; Kern, A. D; Capra, J. A; and Phillips, P. C Genetics, 217(1): iyaa015. 2021.
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Caenorhabditis Intervention Testing Program: the herbicide diuron does not robustly extend lifespan in nematodes. Osman, H. C; Sedore, C. A; Jackson, E G.; Battistoni, E. T; Hall, D.; Foulger, A.; Lucanic, M.; Guo, M.; Driscoll, M.; Phillips, P.; and others Micropublication Biology, 2021. 2021.
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High-throughput imaging of Caenorhabditis elegans aging using collective activity monitoring. Fouad, A. D; Churgin, M. A; Hayden, J.; Xu, J.; Park, J.; Liu, A.; Teng, C.; Sun, H.; Parrado, M.; Bowlin, P.; and others bioRxiv,2021–10. 2021.
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Genetic data compression and methods of use. Stevenson, Z. C; Banse, S. A; and Phillips, P. C October 28 2021. US Patent App. 17/236,556
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Alignment of genetic differentiation across trophic levels in a fig community. Woodruff, G. C; Willis, J. H; and Phillips, P. C bioRxiv,2021–12. 2021.
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  2020 (8)
Modeling Evolutionary Theories. PHILLIPS, P. C The Theory of Evolution: Principles, Concepts, and Assumptions,64. 2020.
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Chromosome-level assembly of the Caenorhabditis remanei genome reveals conserved patterns of nematode genome organization. Teterina, A. A; Willis, J. H; and Phillips, P. C Genetics, 214(4): 769–780. 2020.
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Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes. Coleman-Hulbert, A. L; Johnson, E.; Sedore, C. A; Banse, S. A; Guo, M.; Driscoll, M.; Lithgow, G. J; and Phillips, P. C microPublication Biology, 2020. 2020.
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Sexually antagonistic selection on genetic variation is rare in humans. Kasimatis, K. R; Abraham, A.; Ralph, P. L; Kern, A. D; Capra, J.; and Phillips, P. bioRxiv. 2020.
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Rapid self-selecting and clone-free integration of transgenes into engineered CRISPR safe harbor locations in Caenorhabditis elegans. Stevenson, Z. C; Moerdyk-Schauwecker, M. J; Jamison, B.; and Phillips, P. C G3: Genes, Genomes, Genetics, 10(10): 3775–3782. 2020.
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Caenorhabditis Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes. Morshead, M. L; Sedore, C. A; Jones, E G.; Hall, D.; Plummer, W T.; Garrett, T.; Lucanic, M.; Guo, M.; Driscoll, M.; Phillips, P. C; and others Micropublication Biology, 2020. 2020.
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Opposing directions of stage-specific body length change in a close relative of C. elegans. Hammerschmith, E. W; Woodruff, G. C; and Phillips, P. C bioRxiv,2020–06. 2020.
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A simplified design for the C. elegans lifespan machine. Abbott, M.; Banse, S. A; Melentijevic, I.; Jarrett, C. M; Ange, J. S.; Sedore, C. A; Falkowski, R.; Blue, B. W; Coleman-Hulbert, A. L; Johnson, E.; and others Journal of Biological Methods, 7(4). 2020.
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  2019 (9)
Environmental and evolutionary drivers of the modular gene regulatory network underlying phenotypic plasticity for stress resistance in the nematode Caenorhabditis remanei. Sikkink, K. L; Reynolds, R. M; Ituarte, C. M; Cresko, W. A; and Phillips, P. C G3: Genes, Genomes, Genetics, 9(3): 969–982. 2019.
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The Stress-Chip: A microfluidic platform for stress analysis in Caenorhabditis elegans. Banse, S. A; Blue, B. W; Robinson, K. J; Jarrett, C. M; and Phillips, P. C PLoS One, 14(5): e0216283. 2019.
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A large close relative of C. elegans is slow-developing but not long-lived. Woodruff, G. C; Johnson, E.; and Phillips, P. C BMC evolutionary biology, 19: 1–14. 2019.
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Limits to genomic divergence under sexually antagonistic selection. Kasimatis, K. R; Ralph, P. L; and Phillips, P. C G3: Genes, Genomes, Genetics, 9(11): 3813–3824. 2019.
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Males, outcrossing, and sexual selection in Caenorhabditis nematodes. Cutter, A. D; Morran, L. T; and Phillips, P. C Genetics, 213(1): 27–57. 2019.
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Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventions. Banse, S. A; Lucanic, M.; Sedore, C. A; Coleman-Hulbert, A. L; Plummer, W T.; Chen, E.; Kish, J. L; Hall, D.; Onken, B.; Presley, M. P; and others Geroscience, 41: 945–960. 2019.
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Caenorhabditis Intervention Testing Program: the tyrosine kinase inhibitor imatinib mesylate does not extend lifespan in nematodes. Coleman-Hulbert, A. L; Johnson, E.; Sedore, C. A; Banse, S. A; Guo, M.; Driscoll, M.; Lithgow, G. J; and Phillips, P. C microPublication Biology, 2019. 2019.
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An open source microfluidic sorter for Caenorhabditis nematodes. Timmermeyer, N.; Banse, S. A; North, J. H; Sottile, M.; Lockery, S. R; and Phillips, P. C bioRxiv,780502. 2019.
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A naturally segregating polymorphism balancing semelparous reproduction versus reproductive diapause revealed via microfluidic assessment of starvation stress in Caenorhabditis elegans. Archer, H.; Banse, S.; Blue, B.; and Phillips, P. C bioRxiv,863878. 2019.
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  2018 (8)
Dramatic evolution of body length due to postembryonic changes in cell size in a newly discovered close relative of Caenorhabditis elegans. Woodruff, G. C; Willis, J. H; and Phillips, P. C Evolution Letters, 2(4): 427–441. 2018.
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Rapid gene family evolution of a nematode sperm protein despite sequence hyper-conservation. Kasimatis, K. R; and Phillips, P. C G3: Genes, Genomes, Genetics, 8(1): 353–362. 2018.
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Two levels of host-specificity in a fig-associated Caenorhabditis. Woodruff, G. C; and Phillips, P. C bioRxiv,261958. 2018.
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Auxin-mediated sterility induction system for longevity and mating studies in Caenorhabditis elegans. Kasimatis, K. R; Moerdyk-Schauwecker, M. J; and Phillips, P. C G3: Genes, Genomes, Genetics, 8(8): 2655–2662. 2018.
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Proteomic and evolutionary analyses of sperm activation identify uncharacterized genes in Caenorhabditis nematodes. Kasimatis, K. R; Moerdyk-Schauwecker, M. J; Timmermeyer, N.; and Phillips, P. C BMC genomics, 19: 1–13. 2018.
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Field studies reveal a close relative of C. elegans thrives in the fresh figs of Ficus septica and disperses on its Ceratosolen pollinating wasps. Woodruff, G. C; and Phillips, P. C BMC ecology, 18: 1–16. 2018.
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Reproducibility & Robustness in Pursuing Life-Extending Compounds: Caenorhabditis Intervention Testing Program. Phillips, P; Lithgow, G.; and Driscoll, M Innovation in Aging, 2(Suppl 1): 808. 2018.
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Experimental evolution of independent genetic pathways for resistance to Pseudomonas aeruginosa pathogenicity within the nematode Caenorhabditis remanei. Archer, H.; and Phillips, P. C bioRxiv,484998. 2018.
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  2017 (8)
Metagenome-assembled draft genome sequence of a novel microbial Stenotrophomonas maltophilia strain isolated from Caenorhabditis remanei tissue. Fierst, J. L; Murdock, D. A; Thanthiriwatte, C.; Willis, J. H; and Phillips, P. C Genome Announcements, 5(7): 10–1128. 2017.
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Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects. Lucanic, M.; Plummer, W T.; Chen, E.; Harke, J.; Foulger, A. C; Onken, B.; Coleman-Hulbert, A. L; Dumas, K. J; Guo, S.; Johnson, E.; and others Nature communications, 8(1): 14256. 2017.
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Experimental evolution with Caenorhabditis nematodes. Teotónio, H.; Estes, S.; Phillips, P. C; and Baer, C. F Genetics, 206(2): 691–716. 2017.
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A long journey to reproducible results. Lithgow, G. J; Driscoll, M.; and Phillips, P. Nature, 548(7668): 387–388. 2017.
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Genomic signatures of sexual conflict. Kasimatis, K. R; Nelson, T. C; and Phillips, P. C Journal of Heredity, 108(7): 780–790. 2017.
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Quantifying male and female pheromone-based mate choice in Caenorhabditis nematodes using a novel microfluidic technique. Borne, F.; Kasimatis, K. R; and Phillips, P. C PloS one, 12(12): e0189679. 2017.
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CITP: SCREENING CHEMICALS FOR REPRODUCIBLE AND ROBUST EFFECTS ACROSS DIVERSE GENETIC BACKGROUNDS. Lucanic, M; Guo, M; Lithgow, G.; Driscoll, M; and Phillips, P Innovation in Aging, 1(suppl_1): 1237–1237. 2017.
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Standardized Protocols from the Caenorhabditis Intervention Testing Program 2013-2016: conditions and assays used for quantifying the development, fertility and lifespan of hermaphroditic Caenorhabditis strains. Lucanic, M.; Driscoll, M.; Plummer, W T.; Harke, J.; Chen, E.; Bhaumik, D.; Harinath, G.; Coleman-Hulbert, A.; Dumas, K.; Onken, B.; and others . 2017.
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  2016 (5)
Intrinsic differences between males and females determine sex-specific consequences of inbreeding. Ebel, E. R; and Phillips, P. C BMC Evolutionary Biology, 16: 1–10. 2016.
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Evolution: five heads are better than one. Phillips, P. C Current Biology, 26(7): R283–R285. 2016.
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Comparative genomic analysis of upstream miRNA regulatory motifs in Caenorhabditis. Jovelin, R.; Krizus, A.; Taghizada, B.; Gray, J. C; Phillips, P. C; Claycomb, J. M; and Cutter, A. D RNA, 22(7): 968–978. 2016.
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High-specificity detection of rare alleles with paired-end low error sequencing (PELE-Seq). Preston, J. L; Royall, A. E; Randel, M. A; Sikkink, K. L; Phillips, P. C; and Johnson, E. A BMC genomics, 17: 1–21. 2016.
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Coevolutionary interactions with parasites constrain the spread of self-fertilization into outcrossing host populations. Slowinski, S. P; Morran, L. T; Parrish, R. C; Cui, E. R; Bhattacharya, A.; Lively, C. M; and Phillips, P. C Evolution, 70(11): 2632–2639. 2016.
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  2015 (6)
Modeling the evolution of complex genetic systems: The gene network family tree. Fierst, J. L; and Phillips, P. C Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 324(1): 1–12. 2015.
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The locus of sexual selection: moving sexual selection studies into the post-genomics era. Wilkinson, G. S; Breden, F.; Mank, J. E; Ritchie, M. G; Higginson, A. D; Radwan, J.; Jaquiery, J.; Salzburger, W.; Arriero, E.; Barribeau, S.; and others Journal of evolutionary biology, 28(4): 739–755. 2015.
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Cell biology: scaling and the emergence of evolutionary cell biology. Phillips, P. C; and Bowerman, B. Current Biology, 25(6): R223–R225. 2015.
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Environmentally induced changes in correlated responses to selection reveal variable pleiotropy across a complex genetic network. Sikkink, K. L; Reynolds, R. M; Cresko, W. A; and Phillips, P. C Evolution, 69(5): 1128–1142. 2015.
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Natural and experimental evolution of sexual conflict within Caenorhabditis nematodes. Palopoli, M. F; Peden, C.; Woo, C.; Akiha, K.; Ary, M.; Cruze, L.; Anderson, J. L; and Phillips, P. C BMC evolutionary biology, 15: 1–13. 2015.
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Reproductive mode and the evolution of genome size and structure in Caenorhabditis nematodes. Fierst, J. L; Willis, J. H; Thomas, C. G; Wang, W.; Reynolds, R. M; Ahearne, T. E; Cutter, A. D; and Phillips, P. C PLoS genetics, 11(6): e1005323. 2015.
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  2014 (5)
Rapid evolution of phenotypic plasticity and shifting thresholds of genetic assimilation in the nematode Caenorhabditis remanei. Sikkink, K. L; Reynolds, R. M; Ituarte, C. M; Cresko, W. A; and Phillips, P. C G3: Genes, Genomes, Genetics, 4(6): 1103–1112. 2014.
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Hermaphrodite life history and the maintenance of partial selfing in experimental populations of Caenorhabditis elegans. Carvalho, S.; Phillips, P. C; and Teotónio, H. BMC evolutionary biology, 14: 1–10. 2014.
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A recent global selective sweep on the age-1 phosphatidylinositol 3-OH kinase regulator of the insulin-like signaling pathway within Caenorhabditis remanei. Jovelin, R.; Comstock, J. S; Cutter, A. D; and Phillips, P. C G3: Genes, Genomes, Genetics, 4(6): 1123–1133. 2014.
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The transgenerational effects of heat stress in the nematode Caenorhabditis remanei are negative and rapidly eliminated under direct selection for increased stress resistance in larvae. Sikkink, K. L; Ituarte, C. M; Reynolds, R. M; Cresko, W. A; and Phillips, P. C Genomics, 104(6): 438–446. 2014.
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Rapid Evolution of Phenotypic Plasticity and Shifting Thresholds of Genetic Assimilation in the. Sikkink, K. L; Reynolds, R. M; Ituarte, C. M; Cresko, W. A; and Phillips, P. C . 2014.
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  2013 (2)
Natural variation for lifespan and stress response in the nematode Caenorhabditis remanei. Reynolds, R. M; and Phillips, P. C PLoS One, 8(4): e58212. 2013.
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Daily temperature fluctuations unpredictably influence developmental rate and morphology at a critical early larval stage in a frog. Arrighi, J. M; Lencer, E. S; Jukar, A.; Park, D.; Phillips, P. C; and Kaplan, R. H BMC ecology, 13: 1–11. 2013.
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  2012 (6)
Independent axes of genetic variation and parallel evolutionary divergence of opercle bone shape in threespine stickleback. Kimmel, C. B; Cresko, W. A; Phillips, P. C; Ullmann, B.; Currey, M.; von Hippel, F.; Kristjansson, B. K; Gelmond, O.; and McGuigan, K. Evolution, 66(2): 419–434. 2012.
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Experimental evolution of the Caenorhabditis elegans sex determination pathway. Chandler, C. H; Chadderdon, G. E; Phillips, P. C; Dworkin, I.; and Janzen, F. J Evolution, 66(1): 82–93. 2012.
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Self-fertilization sweeps up variation in the worm genome. Phillips, P. C Nature genetics, 44(3): 237–238. 2012.
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Fertility/longevity trade-offs under limiting-male conditions in mating populations of Caenorhabditis elegans. Wu, D.; Tedesco, P. M; Phillips, P. C; and Johnson, T. E Experimental gerontology, 47(10): 759–763. 2012.
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Variance in epistasis links gene regulation and evolutionary rate in the yeast genetic interaction network. Fierst, J. L; and Phillips, P. C Genome biology and evolution, 4(11): 1080–1087. 2012.
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More than the sum of its parts: a complex epistatic network underlies natural variation in thermal preference behavior in Caenorhabditis elegans. Gaertner, B. E; Parmenter, M. D; Rockman, M. V; Kruglyak, L.; and Phillips, P. C Genetics, 192(4): 1533–1542. 2012.
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  2011 (6)
Does thermoregulatory behavior maximize reproductive fitness of natural isolates of Caenorhabditis elegans?. Anderson, J. L; Albergotti, L.; Ellebracht, B.; Huey, R. B; and Phillips, P. C BMC evolutionary biology, 11: 1–10. 2011.
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Expression level drives the pattern of selective constraints along the insulin/Tor signal transduction pathway in Caenorhabditis. Jovelin, R.; and Phillips, P. C Genome biology and evolution, 3: 715–722. 2011.
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Fitness recovery and compensatory evolution in natural mutant lines of C. elegans. Estes, S.; Phillips, P. C; and Denver, D. R Evolution, 65(8): 2335–2344. 2011.
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Experimental evolution reveals antagonistic pleiotropy in reproductive timing but not life span in Caenorhabditis elegans. Anderson, J. L; Reynolds, R. M; Morran, L. T; Tolman-Thompson, J.; and Phillips, P. C Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 66(12): 1300–1308. 2011.
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Microfluidic devices for analysis of spatial orientation behaviors in semi-restrained Caenorhabditis elegans. McCormick, K. E; Gaertner, B. E; Sottile, M.; Phillips, P. C; and Lockery, S. R PloS one, 6(10): e25710. 2011.
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  2010 (7)
Genotype to phenotype: a complex problem. Dowell, R. D; Ryan, O.; Jansen, A.; Cheung, D.; Agarwala, S.; Danford, T.; Bernstein, D. A; Rolfe, P A.; Heisler, L. E; Chin, B.; and others Science, 328(5977): 469–469. 2010.
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Outcrossing and the maintenance of males within C. elegans populations. Anderson, J. L; Morran, L. T; and Phillips, P. C Journal of heredity, 101(suppl_1): S62–S74. 2010.
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A test of the conjecture that G-matrices are more stable than B-matrices. Barker, B. S; Phillips, P. C; and Arnold, S. J Evolution, 64(9): 2601–2613. 2010.
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Using population genomics to detect selection in natural populations: key concepts and methodological considerations. Hohenlohe, P. A; Phillips, P. C; and Cresko, W. A International journal of plant sciences, 171(9): 1059–1071. 2010.
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Selective sweeps and parallel mutation in the adaptive recovery from deleterious mutation in Caenorhabditis elegans. Denver, D. R; Howe, D. K; Wilhelm, L. J; Palmer, C. A; Anderson, J. L; Stein, K. C; Phillips, P. C; and Estes, S. Genome research, 20(12): 1663–1671. 2010.
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Purging deleterious mutations under self fertilization: paradoxical recovery in fitness with increasing mutation rate in Caenorhabditis elegans. Morran, L. T; Ohdera, A. H; and Phillips, P. C PLoS One, 5(12): e14473. 2010.
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Caenorhabditis elegans as a platform for molecular quantitative genetics and the systems biology of natural variation. Gaertner, B. E; and Phillips, P. C Genetics research, 92(5-6): 331–348. 2010.
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  2009 (5)
Mutation load and rapid adaptation favour outcrossing over self-fertilization. Morran, L. T; Parmenter, M. D; and Phillips, P. C Nature, 462(7271): 350–352. 2009.
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Sexual partners for the stressed: facultative outcrossing in the self-fertilizing nematode Caenorhabditis elegans. Morran, L. T; Cappy, B. J; Anderson, J. L; and Phillips, P. C Evolution, 63(6): 1473–1482. 2009.
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Evolutionary rates and centrality in the yeast gene regulatory network. Jovelin, R.; and Phillips, P. C Genome biology, 10: 1–10. 2009.
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High nucleotide divergence in developmental regulatory genes contrasts with the structural elements of olfactory pathways in Caenorhabditis. Jovelin, R.; Dunham, J. P; Sung, F. S; and Phillips, P. C Genetics, 181(4): 1387–1397. 2009.
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The evolution of sex-determining mechanisms: lessons from temperature-sensitive mutations in sex determination genes in Caenorhabditis elegans. Chandler, C.; Phillips, P.; and Janzen, F. Journal of evolutionary biology, 22(1): 192–200. 2009.
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  2008 (4)
Epistasis—the essential role of gene interactions in the structure and evolution of genetic systems. Phillips, P. C Nature Reviews Genetics, 9(11): 855–867. 2008.
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Natural transformation increases the rate of adaptation in the human pathogen Helicobacter pylori. Baltrus, D. A; Guillemin, K.; and Phillips, P. C Evolution, 62(1): 39–49. 2008.
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Beyond induced mutants: using worms to study natural variation in genetic pathways. Kammenga, J. E; Phillips, P. C; De Bono, M.; and Doroszuk, A. Trends in Genetics, 24(4): 178–185. 2008.
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Who shouldn't be your daddy. Phillips, P. C Nature, 451(7179): 640–641. 2008.
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  2007 (4)
Studies of threespine stickleback developmental evolution: progress and promise. Cresko, W. A; McGuigan, K. L; Phillips, P. C; and Postlethwait, J. H Genetica, 129: 105–126. 2007.
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Thermal preference of Caenorhabditis elegans: a null model and empirical tests. Anderson, J. L; Albergotti, L.; Proulx, S.; Peden, C.; Huey, R. B; and Phillips, P. C Journal of Experimental Biology, 210(17): 3107–3116. 2007.
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Selection against males in Caenorhabditis elegans under two mutational treatments. Manoel, D.; Carvalho, S.; Phillips, P. C; and Teotonio, H. Proceedings of the Royal Society B: Biological Sciences, 274(1608): 417–424. 2007.
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What maintains genetic variation in natural populations? A commentary on ‘The maintenance of genetic variability by mutation in a polygenic character with linked loci’by Russell Lande. Phillips, P. C Genetics Research, 89(5-6): 371–372. 2007.
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  2006 (8)
Exploring the evolution of environmental sex determination, especially in reptiles. Janzen, F. J; and Phillips, P. C Journal of evolutionary biology, 19(6): 1775–1784. 2006.
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Ecological and developmental context of natural selection: maternal effects and thermally induced plasticity in the frog Bombina orientalis. Kaplan, R. H; and Phillips, P. C Evolution, 60(1): 142–156. 2006.
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Allelic divergence precedes and promotes gene duplication. Proulx, S. R; and Phillips, P. C Evolution, 60(5): 881–892. 2006.
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Genetic variation for outcrossing among Caenorhabditis elegans isolates. Teotónio, H.; Manoel, D.; and Phillips, P. C Evolution, 60(6): 1300–1305. 2006.
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Relaxed selection among duplicate floral regulatory genes in Lamiales. Aagaard, J. E; Willis, J. H; and Phillips, P. C Journal of molecular evolution, 63: 493–503. 2006.
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One perfect worm. Phillips, P. C TRENDS in Genetics, 22(8): 405–407. 2006.
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Variation in pleiotropy and the mutational underpinnings of the G-matrix. Estes, S.; and Phillips, P. C Evolution, 60(12): 2655–2660. 2006.
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Evolution of genetic variance–covariance structure. Phillips, P.; and McGuigan, K. Evolutionary genetics: concepts and case studies. Oxford Univ. Press, Oxford, England,310–325. 2006.
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  2005 (10)
Network thinking in ecology and evolution. Proulx, S. R; Promislow, D. E.; and Phillips, P. C Trends in ecology & evolution, 20(6): 345–353. 2005.
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The opportunity for canalization and the evolution of genetic networks. Proulx, S. R; and Phillips, P. C The American Naturalist, 165(2): 147–162. 2005.
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Evolution and development of facial bone morphology in threespine sticklebacks. Kimmel, C. B; Ullmann, B.; Walker, C.; Wilson, C.; Currey, M.; Phillips, P. C; Bell, M. A; Postlethwait, J. H; and Cresko, W. A Proceedings of the National Academy of Sciences, 102(16): 5791–5796. 2005.
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Spontaneous mutational correlations for life-history, morphological and behavioral characters in Caenorhabditis elegans. Estes, S.; Ajie, B. C; Lynch, M.; and Phillips, P. C Genetics, 170(2): 645–653. 2005.
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Testing hypotheses regarding the genetics of adaptation. Phillips, P. C Genetica, 123: 15–24. 2005.
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Behavioral degradation under mutation accumulation in Caenorhabditis elegans. Ajie, B. C; Estes, S.; Lynch, M.; and Phillips, P. C Genetics, 170(2): 655–660. 2005.
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Duplication of floral regulatory genes in the Lamiales. Aagaard, J. E; Olmstead, R. G; Willis, J. H; and Phillips, P. C American Journal of Botany, 92(8): 1284–1293. 2005.
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Accuracy and power of the likelihood ratio test for comparing evolutionary rates among genes. Aagaard, J. E.; and Phillips, P. Journal of molecular evolution, 60: 426–433. 2005.
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Functional constraint and divergence in the G protein family in Caenorhabditis elegans and Caenorhabditis briggsae. Jovelin, R.; and Phillips, P. C Molecular Genetics and Genomics, 273: 299–310. 2005.
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Characterization of thermal reaction norms for sex ratio in two mutant lines of Caenorhabditis elegans. Chandler, C.; Phillips, P.; and Janzen, F. In INTEGRATIVE AND COMPARATIVE BIOLOGY, volume 45, pages 1117–1117, 2005. OXFORD UNIV PRESS INC JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
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  2004 (4)
Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations. Cresko, W. A; Amores, A.; Wilson, C.; Murphy, J.; Currey, M.; Phillips, P.; Bell, M. A; Kimmel, C. B; and Postlethwait, J. H Proceedings of the National Academy of Sciences, 101(16): 6050–6055. 2004.
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Power and potential bias in field studies of natural selection. Hersch, E. I; and Phillips, P. C Evolution, 58(3): 479–485. 2004.
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Mutation accumulation in populations of varying size: the distribution of mutational effects for fitness correlates in Caenorhabditis elegans. Estes, S.; Phillips, P. C; Denver, D. R; Thomas, W K.; and Lynch, M. Genetics, 166(3): 1269–1279. 2004.
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Evolution of sarcomeric myosin heavy chain genes: evidence from fish. McGuigan, K.; Phillips, P. C; and Postlethwait, J. H Molecular biology and evolution, 21(6): 1042–1056. 2004.
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  2003 (1)
Molecular evolution and quantitative variation for chemosensory behaviour in the nematode genus Caenorhabditis. Jovelin, R; Ajie, B.; and Phillips, P. Molecular ecology, 12(5): 1325–1337. 2003.
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  2002 (3)
Comparative quantitative genetics: evolution of the G matrix. Steppan, S. J; Phillips, P. C; and Houle, D. Trends in ecology & evolution, 17(7): 320–327. 2002.
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Selection and maintenance of androdioecy in Caenorhabditis elegans. Stewart, A. D; and Phillips, P. C Genetics, 160(3): 975–982. 2002.
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Persistence of changes in the genetic covariance matrix after a bottleneck. Whitlock, M. C; Phillips, P. C; and Fowler, K. Evolution, 56(10): 1968–1975. 2002.
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  2001 (3)
Inbreeding changes the shape of the genetic covariance matrix in Drosophila melanogaster. Phillips, P. C; Whitlock, M. C; and Fowler, K. Genetics, 158(3): 1137–1145. 2001.
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Drift: Introduction. Whitlock, M. C; and Phillips, P. C e LS. 2001.
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H2Boot. Phillips, P. University of Oregon, Eugene, Ore. 2001.
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  2000 (2)
Beyond the average: the evolutionary importance of gene interactions and variability of epistatic effects. Phillips, P. C; Otto, S. P; Whitlock, M. C; Wolf, J.; Brodie, E.; and Wade, M. Epistasis and the evolutionary process,20–38. 2000.
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The exquisite corpse: a shifting view of the shifting balance. Whitlock, M. C; and Phillips, P. C Trends in Ecology & Evolution, 15(9): 347–348. 2000.
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  1999 (3)
Hierarchical comparison of genetic variance-covariance matrices. I. Using the Flury hierarchy. Phillips, P. C; and Arnold, S. J Evolution, 53(5): 1506–1515. 1999.
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HIERARCHICAL COMPARISON OF GENETIC VARIANCE-COVARIANCE MATRICES. II COASTAL-INLAND DIVERGENCE IN THE GARTER SNAKE, THAMNOPHIS ELEGANS. Arnold, S. J; and Phillips, P. C Evolution, 53(5): 1516–1527. 1999.
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From complex traits to complex alleles. Phillips, P. C Trends in Genetics, 15(1): 6–8. 1999.
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  1998 (8)
The language of gene interaction. Phillips, P. C Genetics, 149(3): 1167–1171. 1998.
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The population genetics of synthetic lethals. Phillips, P. C; and Johnson, N. A Genetics, 150(1): 449–458. 1998.
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Designing experiments to maximize the power of detecting correlations. Phillips, P. C Evolution, 52(1): 251–255. 1998.
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Genetic constraints at the metamorphic boundary: morphological development in the wood frog, Rana sylvatica. Phillips, P. Journal of Evolutionary Biology, 11(4): 453–463. 1998.
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H2boot: bootstrap estimates and tests of quantitative genetic data. Phillips, P. University of Texas at Arlington. 1998.
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CPC: common principal components analysis. Phillips, P. University of Texas at Arlington. Software available at www. uta. edu/biology/phillips/software, 8. 1998.
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CPCrand: randomization test of the CPC hierarchy. Phillips, P. University of Texas at Arlington. Software available at www. uta. edu/biology/phillips/software. 1998.
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CPC: common principal component analysis program. Phillips, P. Program and documentation available via http://www. uta. edu/biology/phillips/software. html. 1998.
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  1997 (1)
The rise and fall of new mutations. Phillips, P. C . 1997.
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  1996 (2)
Waiting for a compensatory mutation: phase zero of the shifting-balance process. Phillips, P. C Genetics Research, 67(3): 271–283. 1996.
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Maintenance of polygenic variation via a migration-selection balance under uniform selection. Phillips, P. C Evolution,1334–1339. 1996.
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  1995 (1)
Multiple fitness peaks and epistasis. Whitlock, M. C; Phillips, P. C; Moore, F. B.; and Tonsor, S. J Annual review of ecology and systematics, 26(1): 601–629. 1995.
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  1993 (2)
Gene interaction affects the additive genetic variance in subdivided populations with migration and extinction. Whitlock, M. C; Phillips, P. C; and Wade, M. J Evolution, 47(6): 1758–1769. 1993.
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Peak shifts and polymorphism during phase three of Wright's shifting-balance process. Phillips, P. C Evolution, 47(6): 1733–1743. 1993.
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  1992 (1)
Snowbird Resort Snowbird, Utah. Huey, R; Harshman, L; Farrell, B; Honeycutt, R; Li, W.; Phillips, P; Crow, J; Wade, M; and Rogers, A. Evolution, 46(6): 1990–1992. 1992.
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  1991 (1)
A genetic and functional analysis of larval development in the wood frog, Rana sylvatica. PHILLIPS, P. C. Ph.D. Thesis, The University of Chicago, 1991.
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  1990 (1)
Guliahs, s.". Phillips, P. C. Asymptotic Properties of Residual Based Tests for C0integration," 2COllot77cf7ica, yol, 58: 165–193. 1990.
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  1989 (1)
Visualizing multivariate selection. Phillips, P. C; and Arnold, S. J Evolution, 43(6): 1209–1222. 1989.
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  1987 (1)
A personal computer-microscope interface for the analysis of size and shape. Phillips, P. C; and Kaplan, R. H Herpetologica, 43(3): 384–385. 1987.
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  1955 (1)
BUTYROSPERMOL AND BASSEOL. Dawson, M.; Halsall, T.; Jones, E.; Meakins, G.; and Phillips, P. 1955.
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  undefined (3)
A recent global selective sweep on the age-1 PI3 kinase regulator of the insulin-like signaling pathway within Caenorhabditis remanei. Jovelin, R.; Comstock, J. S; Cutter, A. D; and Phillips, P. C . .
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shifting-balance process. PHILLIPS, P. C . .
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Ouliaris. S.(1990). Asymptotic Properties of Residual Based Tests for Cintegration. Economatrica. Phillips, P. Journal of Econometric Society,165–193. .
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