| Mile | City | Pop. | Inc? | Details |
| Clatsop County | ||||
| 3 | Astoria ☆ | 9,477 | ✓ | |
| 6 | Warrenton | 5,282 | ✓ | |
| 20 | Seaside | 6,457 | ✓ | |
| 28 | Cannon Beach | 1,690 | ✓ | See Ecola SP, Haystack Rock, Arch Cape. |
| Tillamook County | ||||
| 43 | Manzanita | 598 | ✓ | See Oswald West SP and Nehalem Bay SP. |
| 46 | Nehalem | 271 | ✓ | Incorporated. |
| 49 | Rockaway Beach | 1,312 | ✓ | Incorporated. |
| 64 | Tillamook ☆ | 4,935 | ✓ | See Three Capes Loop. |
| 84 | Hebo | 231 | Nestucca River. | |
| 90 | Pacific City | 1,027 | See Cape Kiwanda and Three Capes Loop. | |
| 97 | Neskowin | 170 | See Neskowin Beach State Recreation Site, Neskowin Ghost Forest, and Cascade Head. | |
| Lincoln County | ||||
| 115 | Lincoln City | 9,017 | ✓ | See Cascade Head, Road's End, Devil's Lake, Siletz Bay. |
| 122 | Gleneden Beach | ~500 | See Salishan Spit and Gleneden Beach State Recreation Site. | |
| 127 | Depoe Bay | 1,398 | ✓ | |
| 138 | Newport ☆ | 10,680 | ✓ | See Cape Foulweather / Otter Crest, Yaquina Head, Yaquina Bay, and South Beach SP. |
| n/a | Toledo | 3,465 | ✓ | Five miles east of US101/Newport on US20. |
| 150 | Seal Rock | ? | Unincoporated. Seal Rock SP. | |
| 155 | Bayshore | ? | Unincoporated. | |
| 156 | Waldport | 2,033 | ✓ | Alsea River, OR 34. |
| 164 | Yachats | 690 | ✓ | See Cape Perpetua. |
| Lane County | ||||
| 190 | Florence | 8,466 | ✓ | See Heceta Head, Oregon Dunes. |
| Douglas County | ||||
| 209 | Gardiner | 248 | Unincorporated. | |
| 211 | Reedsport | 4,154 | ✓ | Umpqua River. |
| 215 | Winchester Bay | 382 | Unincorporated. | |
| Coos County | ||||
| 222 | Lakeside | 1,699 | ✓ | Incorporated. |
| 235 | North Bend | 9,695 | ✓ | |
| 238 | Coos Bay | 15,967 | ✓ | Most populous city on the Oregon Coast. |
| n/a | Coquille ☆ | 3,866 | ✓ | Located inland, east of US 101, where OR42 and OR42S meet. |
| 264 | Bandon | 3,066 | ✓ | See . . . all of it. |
| Curry County | ||||
| 287 | Langlois | 177 | Unincorporated. | |
| 300 | Port Orford | 1,133 | ✓ | Nice! |
| 328 | Gold Beach ☆ | 2,253 | ✓ | Curry County seat. |
| 355 | Brookings | 6,336 | ✓ | |
| 358 | Harbor | 2,391 | Unincorporated, and often combined with Brookings. | |